ea0034oc1.1 | Young Endocrinologists prize session | SFEBES2014
Taylor Peter
, Okosieme Onyebuchi
, Sayers Adrian
, Northstone Kate
, Draman Mohd
, Stevenson Kirsty
, Woltersdorf Wolf
, Taylor Andrew
, Pearce Elizabeth
, Panicker Vijay
, Ludgate Marian
, Gregory John
, Lazarus John
, Timpson Nicholas
, Channon Sue
, Dayan Colin
Importance: Thyroid hormone is essential for cognitive development. The Thr92Ala substitution in deiodonase-2 appears to reduce intracellular availability of active thyroid hormone. Individuals with low-normal serum thyroid hormone levels and this substitution might have insufficient intracellular thyroid hormone for optimal cognitive development.Objective: To explore whether individuals with low thyroid hormone bioavailability free thyroxine in t...